4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 53135-24-3
• Molecular Formula: C8H10 N2 O3
• Molecular Weight: 182.179
• Hs Code.: 2933599090
• Mol file: 53135-24-3.mol

Synonyms:5-Pyrimidinecarboxylicacid, 1,4-dihydro-2-methyl-4-oxo-, ethyl ester (9CI); Ethyl 2-methyl-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate;Ethyl 3,4-dihydro-2-methyl-4-oxopyrimidine-5-carboxylate; Ethyl4-hydroxy-2-methyl-5-pyrimidine carboxylate; NSC 160874

Chemical Property of 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00482mmHg at 25°C
• Melting Point: 191-194°C
• Boiling Point: 267.9°Cat760mmHg
• PKA: 8.11±0.50(Predicted)
• Flash Point: 115.8°C
• PSA: 72.31000
• Density: 1.28g/cm³
• LogP: 0.66730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-Hydroxy-2-methylpyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

There total 10 articles about 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

acetamidine hydrochloride (124-42-5) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate (53135-24-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.0c02093

Reference yield: 61.0%

ethanimidamide hydrochloride + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate (53135-24-3)

Guidance literature:

ethanimidamide hydrochloride; With sodium; In ethanol; at 0 ℃; for 0.333333h;

diethyl 2-ethoxymethylenemalonate; With triethylamine; In ethanol; at 0 ℃; for 2.5h; Reflux;

Reference yield: 46.0%

acetamidine acetate (36896-17-0) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate (53135-24-3)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/S0960-894X(97)00258-8

upstream raw materials:

acetamidine hydrochloride

diethyl 2-ethoxymethylenemalonate

acetamidine acetate

acetamidine

Downstream raw materials:

ethyl 4-chloro-2-methylpyrimidine-5-carboxylate

1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

7-(4-amino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

1-(2-fluoro-benzyl)-7-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester