8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one
CAS No.:1169549-69-2
Molecular Formula:C₁₆H₇BrClN₃O₄
Molecular Weight:420.606
Hs Code.:

Synonyms:8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

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Chemical Property of 8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

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Technology Process of 8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

There total 3 articles about 8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5568-33-2
2-chloro-4-nitrobenzaldehyde

: 309922-87-0
3-amino-5-bromobenzofuran-2-carboxamide

: 1169549-69-2
8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: With sodium hydrogensulfite; In dimethyl sulfoxide; at 150 ℃; for 5h;

Reference yield:

: 318259-87-9
2-(4-bromo-2-cyanophenoxy)acetamide

: 1169549-69-2
8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 75 °C

2: sodium hydrogensulfite / dimethyl sulfoxide / 5 h / 150 °C

With sodium hydrogensulfite; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.04.025

Reference yield:

: 40530-18-5
5-bromo-2-hydroxybenzonitrile

: 1169549-69-2
8-bromo-2-(2-chloro-4-nitrophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl acetamide / 75 °C

2: potassium hydroxide / ethanol / 75 °C

3: sodium hydrogensulfite / dimethyl sulfoxide / 5 h / 150 °C

With caesium carbonate; sodium hydrogensulfite; potassium hydroxide; In ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.04.025