5568-33-2

Basic information

• Product Name: 2-Chloro-4-nitrobenzaldehyde
• Synonyms: 2-Chloro-4-nitrobenzaldehyde
• CAS NO: 5568-33-2
• Molecular Formula: C₇H₄ClNO₃
• Molecular Weight: 185.56456
• Mol File: 5568-33-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 74 °C(Solv: ligroine (8032-32-4); water (7732-18-5))
• Boiling Point: 312.4°Cat760mmHg
• Flash Point: 142.7°C
• Appearance: /
• Density: 1.485g/cm³
• Vapor Pressure: 0.000532mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-Chloro-4-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-nitrobenzaldehyde(5568-33-2)
• EPA Substance Registry System: 2-Chloro-4-nitrobenzaldehyde(5568-33-2)

Safety Data

• Hazardous Substances Data: 5568-33-2(Hazardous Substances Data)

Usage

Uses

2-Chloro-4-nitrobenzaldehyde is used in preparation of nitrogen heterocyclic compounds as ErbB inhibitors for the treatment of cancer.

InChI:InChI=1/C7H4ClNO3/c8-7-3-6(9(11)12)2-1-5(7)4-10/h1-4H

Upstream product

• 42533-63-1 1-(bromomethyl)-2-chloro-4-nitrobenzene 
• 85544-62-3 1-dimethylamino-2-(2'-chloro-4'-nitrophenyl)-ethylene 
• 121-86-8 2-chloro-4-nitrotoluene 
• 179687-05-9 2-chloro-N-methoxy-N-methyl-4-nitrobenzamide 
• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 
• 52301-88-9 (2-chloro-4-nitrophenyl)methanol 
• 75-17-2 formaldoxime 
• 77455-54-0 2-chloro-4-nitrobenzal diacetate 
• 64-17-5 ethanol 
• 77455-65-3 3-chloro-4-(dichloromethyl)-1-nitrobenzene 

Downstream Products

• 4402-95-3 3-(2-chloro-4-nitro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester 
• 198821-76-0 3-chloro-4-(oxazol-5-yl)phenylamine 
• 179687-02-6 (2-chloro-4-nitrophenyl)(pyridin-2-yl)methanol 
• 1241398-17-3 4-(2-chloro-4-nitrobenzylideneamino)-3-(1-phenyl-5-(thiophen-2-yl)-1H-pyrazol-3-yl)-1H-1,2,4-triazole-5(4H)-thione 
• 1241398-26-4 N'-(2-chloro-4-nitrobenzylidene)-1-phenyl-5-(thiophen-2-yl)-1H-pyrazole-3-carbohydrazide 
• 28163-00-0 4-nitro-2-chlorobenzonitrile 

Relevant articles and documents

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.

Facile, environmentally friendly synthesis of benzaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives

A facile environmentally friendly synthesis of bezaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives is described. Oxidation of the styrylamines by H2O2 H2O2 affords benzaldehydes in moderate yields, while the hydrolysis of styrylamines afforded phenylacetaldehyde analogs in good yields. Copyright

BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS

A compound according to formula I: or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3a, R3b, R3c and R3d are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.