2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

Base Information

Chemical Name:2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol
CAS No.:1280206-19-0
Molecular Formula:C₁₂H₁₂BrNO₂
Molecular Weight:282.137
Hs Code.:

Synonyms:2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

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Chemical Property of 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

Chemical Property:

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Technology Process of 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

There total 7 articles about 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280206-18-9
[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid ethyl ester

: 1280206-19-0
2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

Guidance literature:: [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280206-19-0
2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride / acetic acid / 1 h / 115 °C

2.1: lithium borohydride; ethanol / 60 °C

3.1: phosphorus tribromide / 1,2-dimethoxyethane / 1 h / 20 °C

4.1: N,N-dimethyl-formamide / 65 °C

5.1: water; sodium hydroxide / ethanol / 3 h / 75 °C

5.2: 20 °C / Acidic conditions

6.1: thionyl chloride / ethanol / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; lithium borohydride; thionyl chloride; ethanol; hydroxylamine hydrochloride; water; phosphorus tribromide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1228689-61-9
methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

: 1280206-19-0
2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium borohydride; ethanol / 60 °C

2.1: phosphorus tribromide / 1,2-dimethoxyethane / 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 65 °C

4.1: water; sodium hydroxide / ethanol / 3 h / 75 °C

4.2: 20 °C / Acidic conditions

5.1: thionyl chloride / ethanol / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; lithium borohydride; thionyl chloride; ethanol; water; phosphorus tribromide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;