1-(1-Adamantyl)cyclohexanol

Base Information

• Chemical Name: 1-(1-Adamantyl)cyclohexanol
• CAS No.: 84213-80-9
• Molecular Formula: C16H26 O
• Molecular Weight: 234.382
• Hs Code.: 2906199090
• Mol file: 84213-80-9.mol

Synonyms:1-Adamantylcyclohexanol

Chemical Property of 1-(1-Adamantyl)cyclohexanol

Chemical Property:

• PSA: 20.23000
• LogP: 3.89800

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-Adamantyl)cyclohexanol

There total 3 articles about 1-(1-Adamantyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-Adamantyl bromide (768-90-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(1-Adamantyl)cyclohexanol (84213-80-9)

Guidance literature:

With lithium; In diethyl ether; for 5h;

DOI:10.1021/jo00083a038

Reference yield: 70.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 1-Adamantyllithium (3732-30-7) → 1-(1-Adamantyl)cyclohexanol (84213-80-9)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 5h; Sonication;

DOI:10.1016/j.tet.2019.06.016

Reference yield:

1-Adamantyl bromide (768-90-1) + n-chlorooctane (111-85-3) → 1-(1-Adamantyl)cyclohexanol (84213-80-9)

Guidance literature:

Grignard-type reactions with organocalcium reagents;

DOI:10.1021/jo00304a016

upstream raw materials:

1-Adamantyl bromide

n-chlorooctane

cyclohexanone

1-Adamantyllithium

Downstream raw materials:

C₁₆H₂₅N₃

Refernces

• 1、 Tzitzoglaki, Christina,Wright, Anna,Freudenberger, Kathrin,Hoffmann, Anja,Tietjen, Ian,Stylianakis, Ioannis,Kolarov, Felix,Fedida, David,Schmidtke, Michaela,Gauglitz, Günter,Cross, Timothy A.,Kolocouris, Antonios. "Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained". supporting information. p. 1716 - 1733. Retrieved 2017/03/17.
• 2、 Kraus, George A.,Siclovan, Tiberiu M.. "Bridgehead Intermediates in Organic Synthesis. A Reproducible Synthesis of Adamantane-Containing Compounds". . p. 922 - 923. Retrieved 2007/10/02.