(3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine

Base Information

Chemical Name:(3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine
CAS No.:1104460-74-3
Molecular Formula:C₂₈H₃₅NO₆
Molecular Weight:481.589
Hs Code.:

Synonyms:(3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine

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Chemical Property of (3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine

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Technology Process of (3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine

There total 1 articles about (3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1104460-72-1,143539-91-7
C₁₈H₂₅NO₅

: 67515-49-5
1-benzyloxyallene

: 1104460-74-3
(3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine

Guidance literature:: 1-benzyloxyallene; With n-butyllithium; In diethyl ether; hexane; at -40 ℃; for 0.25h; Inert atmosphere;

C₁₈H₂₅NO₅; With diethylaluminium chloride; In diethyl ether; hexane; at -78 - 20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol802514m

Reference yield: 63.0%

: 1104460-74-3
(3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine

: 108-24-7
acetic anhydride

: 1104460-78-7
(3R,4S,4'S,4''R,5'R)-2-acetyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-1,2-oxazinane

Guidance literature:: (3S,4'S,4''R,5'R)-2-benzyl-4-(benzyloxy)-3-(2',2',2'',2''-tetramethyl-4',4''-bi-1,3-dioxolan-5'-yl)-3,6-dihydro-2H-1,2-oxazine; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h;

acetic anhydride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol802514m