N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

Base Information

Chemical Name:N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine
CAS No.:211919-86-7
Molecular Formula:C₂₃H₂₉N₅O₃Si
Molecular Weight:451.6
Hs Code.:

N<sup>5</sup>-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

Synonyms:N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

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Technology Process of N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

There total 6 articles about N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 211919-85-6
N⁶-benzoyl-5',8-cyclo-2',5'-dideoxyadenosine

: 211919-86-7
N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1021/jo980083q

Reference yield: 56.0%

: 872131-62-9
(5'S)-N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5'-O-[tris(trimethylsilyl)silyl]-5',8-cyclo-2'-deoxyadenosine

: 211919-86-7
N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

: 211919-88-9
(5?'S)-N⁶-benzoyl-3?'-O-(tert-butyldimethylsilyl)-5?',8-cyclo-2?'-deoxyadenosine

Guidance literature:: In methanol; dichloromethane; for 1.5h; Irradiation;
DOI:10.1002/ejoc.200500398

Reference yield:

: 4546-72-9
N₆-benzoyl-2'-deoxyadenosine

: 211919-86-7
N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5',8-cyclo-2',5-dideoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / 24 h / -20 °C

2: 51 percent / CH₃ONa / methanol / 2 h / Heating

3: 51 percent / triethyl phosphite / acetonitrile / 10 h / Irradiation

4: 79 percent / imidazole / dimethylformamide / 20 h / Ambient temperature

With 1H-imidazole; sodium methylate; triethyl phosphite; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo980083q