p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline

Base Information

• Chemical Name: p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline
• CAS No.: 82815-79-0
• Molecular Formula: C₂₅H₂₅NO
• Molecular Weight: 355.48
• Mol file: 82815-79-0.mol

Synonyms:p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline

Chemical Property of p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline

There total 2 articles about p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N,N-dibenzyl-4-iodobenzenamine (76464-91-0) + 2-methyl-but-3-yn-2-ol (115-19-5) → p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline (82815-79-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; at 50 ℃; for 3h;

DOI:10.1007/BF00949973

Reference yield:

N,N-dibenzylaniline (91-73-6) → p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline (82815-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / I₂, aq. NaHCO₃ / methanol / 3 h / 8 - 20 °C

2: 72 percent / Et₂NH, Pd(PPh₃)2Cl₂, CuI / 3 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; diethylamine; In methanol;

DOI:10.1007/BF00949973

Reference yield: 90.0%

p-(3-methyl-3-hydroxy-1-butynyl)-N,N-dibenzylaniline (82815-79-0) → 4-(N,N-dibenzylamino)-1-ethynylbenzene (82815-80-3)

Guidance literature:

With potassium hydroxide; In toluene; at 80 ℃;

DOI:10.1007/BF00961695

upstream raw materials:

N,N-dibenzyl-4-iodobenzenamine

2-methyl-but-3-yn-2-ol

N,N-dibenzylaniline

Downstream raw materials:

4-(N,N-dibenzylamino)-1-ethynylbenzene

2-Chloro-1-(4-dibenzylamino-phenyl)-ethanone

Refernces