1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

Base Information

Chemical Name:1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine
CAS No.:475596-22-6
Molecular Formula:C₂₇H₂₄F₂N₄O₂
Molecular Weight:474.51
Hs Code.:

Synonyms:1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

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Chemical Property of 1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

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Technology Process of 1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

There total 6 articles about 1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 475595-62-1
1,2-bis(4-fluorophenyl)-1H-imidazole-4-carboxylic acid

: 475596-22-6
1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm020848t

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 475596-22-6
1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: Al(CH₃)3 / toluene / 0 - 20 °C

1.2: 75 percent / toluene / 17 h / 70 °C

2.1: 57 percent / NaHCO₃ / propan-2-ol / 1.5 h / 70 °C

3.1: 85 percent / p-toluenesulfonic acid / toluene / 1.5 h / Heating

4.1: 94 percent / 1 N aq. NaOH / methanol / 1.5 h / Heating

5.1: 65 percent / DCC; HOBt / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; trimethylaluminum; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; isopropyl alcohol; toluene;
DOI:10.1021/jm020848t

Reference yield:

: 371-40-4
4-fluoroaniline

: 475596-22-6
1-{[1,2-bis(4-fluorophenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: Al(CH₃)3 / toluene / 0 - 20 °C

1.2: 75 percent / toluene / 17 h / 70 °C

2.1: 57 percent / NaHCO₃ / propan-2-ol / 1.5 h / 70 °C

3.1: 85 percent / p-toluenesulfonic acid / toluene / 1.5 h / Heating

4.1: 94 percent / 1 N aq. NaOH / methanol / 1.5 h / Heating

5.1: 65 percent / DCC; HOBt / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; trimethylaluminum; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; isopropyl alcohol; toluene;
DOI:10.1021/jm020848t