2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Base Information

• Chemical Name: 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide
• CAS No.: 479195-06-7
• Molecular Formula: C₂₆H₂₇F₆NO₄
• Molecular Weight: 531.495
• Mol file: 479195-06-7.mol

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

There total 5 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide (479195-03-4) → 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide (479195-06-7)

Guidance literature:

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide; With ozone;

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.11.111

Reference yield:

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride (877056-25-2) → 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide (479195-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 60 percent / pyridine / CH₂Cl₂

2.1: 98 percent / p-TSA / toluene

3.1: O₃

3.2: 83 percent / NaBH₄ / methanol; CH₂Cl₂

With pyridine; toluene-4-sulfonic acid; ozone; In dichloromethane; toluene;

DOI:10.1016/j.bmcl.2005.11.111

Reference yield:

(RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid (334477-38-2) → 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide (479195-06-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / (CO₂Cl)2

2.1: 60 percent / pyridine / CH₂Cl₂

3.1: 98 percent / p-TSA / toluene

4.1: O₃

4.2: 83 percent / NaBH₄ / methanol; CH₂Cl₂

With pyridine; (CO₂Cl)2; toluene-4-sulfonic acid; ozone; In dichloromethane; toluene;

DOI:10.1016/j.bmcl.2005.11.111

upstream raw materials:

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride

(RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid

(RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide

Downstream raw materials:

3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-pyrrolidin-2-one

3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one

3-(3,5-bis-trifluoromethyl-phenyl)-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one