4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

Base Information

Chemical Name:4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile
CAS No.:1599525-52-6
Molecular Formula:C₃₁H₂₄ClF₃N₆O₂
Molecular Weight:605.019
Hs Code.:

Synonyms:4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

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Chemical Property of 4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

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Technology Process of 4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

There total 6 articles about 4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599524-55-6
(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone

: 1599524-79-4
4-((6-bromo-4-chloro-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

: 1599525-52-6
4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

Guidance literature:: 4-((6-bromo-4-chloro-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.583333h;

Reference yield:

: 1878-82-6
(4-cyanophenoxy)acetic acid

: 1599525-52-6
4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1.5 h / -78 °C / Cooling with ice

4.1: trichlorophosphate / acetonitrile / 100 °C

5.1: N,N-dimethyl-formamide / 60 - 100 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

6.2: 0.58 h / -78 - 0 °C

With n-butyllithium; oxalyl dichloride; potassium hexamethylsilazane; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 55368-68-8
2-(4-cyanophenoxy)acetyl chloride

: 1599525-52-6
4-((4-chloro-6-(hydroxy(1-methyl-1H-imidazole-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(pyrrolidin-1-yl)quinolin-3-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1.5 h / -78 °C / Cooling with ice

3.1: trichlorophosphate / acetonitrile / 100 °C

4.1: N,N-dimethyl-formamide / 60 - 100 °C

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

5.2: 0.58 h / -78 - 0 °C

With n-butyllithium; potassium hexamethylsilazane; triethylamine; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;