[4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

Base Information

Chemical Name:[4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester
CAS No.:211563-39-2
Molecular Formula:C₂₀H₁₄ClF₃N₂O₅
Molecular Weight:454.79
Hs Code.:

Synonyms:[4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

Suppliers and Price of [4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

There total 2 articles about [4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7693-46-1
4-Nitrophenyl chloroformate

: 209414-27-7,927812-33-7,154598-58-0
(2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol

: 211563-39-2
[4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

Guidance literature:: With potassium hydrogencarbonate; In water; at 20 - 25 ℃; for 1h;
DOI:10.1021/jo981170l

Reference yield:

: 209414-26-6
(S)-6-chloro-4-(cyclopropylethynyl)-2-(4-methoxyphenyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazine

: 211563-39-2
[4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOH, 2.) NaOH, NaBH₄ / 1.) methanol, toluene, 40 deg C, 30 min, 2.) methanol, toluene, room temperature, 15 min

2: potassium bicarbonate / various solvent(s); H₂O / 1 h / 20 - 25 °C

With sodium hydroxide; sodium tetrahydroborate; potassium hydrogencarbonate; In water;
DOI:10.1021/jo981170l

Reference yield:

: 211563-39-2
[4-Chloro-2-((S)-3-cyclopropyl-1-hydroxy-1-trifluoromethyl-prop-2-ynyl)-phenyl]-carbamic acid 4-nitro-phenyl ester

: 154598-52-4,154635-17-3
efavirenz

Guidance literature:: With potassium carbonate; In tetrahydrofuran; methyl t-butyl ether (MTBE); water; at 25 ℃; for 2h; Product distribution / selectivity;