[¹⁸F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine

Base Information

• Chemical Name: [¹⁸F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine
• CAS No.: 1314081-20-3
• Molecular Formula: C₂₅H₂₅FN₆O
• Molecular Weight: 443.513

Synonyms:[¹⁸F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine

Chemical Property of [¹⁸F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine

Chemical Property:

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Technology Process of [¹⁸F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine

There total 13 articles about [¹⁸F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.8%

2-[18F]fluoroethylazide (894793-02-3) + C23H21N3O (1613454-84-4) → [18F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine (1314081-20-3)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere; Cooling with ice;

DOI:10.1039/c3ob42379d

Reference yield:

C35H41(18)FN6O5 (1314081-19-0) → [18F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine (1314081-20-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

Reference yield:

4,4'-dinitro-2-biphenylamine (51787-75-8) → [18F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-5,6-dihydrophenanthridine-3,8-diamine (1314081-20-3)

Guidance literature:

Multi-step reaction with 11 steps

1: chlorobenzene / Reflux

2: ammonium formate / 20 % Pd(OH)2/C

4: trichlorophosphate

5: hydrogen bromide / water

7: potassium carbonate / acetone

8: tetrahydrofuran

9: sodium cyanoborohydride

10: sodium L-ascorbate; copper(II) sulfate / N,N-dimethyl-formamide

11: hydrogenchloride / ethyl acetate

With hydrogenchloride; hydrogen bromide; ammonium formate; sodium cyanoborohydride; potassium carbonate; copper(II) sulfate; sodium L-ascorbate; trichlorophosphate; 20 % Pd(OH)2/C; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; acetone;

upstream raw materials:

4-methoxy-benzoyl chloride

4,4'-dinitro-2-biphenylamine

N-(4,4'-dinitro-[1,1'-biphenyl]-2-yl)-4-methoxybenzamide

N-(4,4'-diamino-[1,1'-biphenyl]-2-yl)-4-methoxybenzamide

Downstream raw materials:

C₂₅H₂₄⁽¹⁸⁾FN₆O⁽¹⁺⁾

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