methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

Base Information

Chemical Name:methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate
CAS No.:1311415-86-7
Molecular Formula:C₃₉H₅₈N₄O₆
Molecular Weight:678.913
Hs Code.:

methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

Synonyms:methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

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Chemical Property of methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

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Technology Process of methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

There total 11 articles about methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₃₈H₅₆N₄O₆

: 1311415-86-7
methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

Guidance literature:: formaldehyd; C₃₈H₅₆N₄O₆; In methanol; at 20 ℃; for 3h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 16h;
DOI:10.1002/ejoc.201100155

Reference yield:

: 1311415-73-2
methyl (S)-3-[2-[(tert-butoxycarbonyl)methylamino]-3-methylbutoxy]benzoate

: 1311415-86-7
methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 °C

2.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -10 - 20 °C / Inert atmosphere

3.1: 10% palladium on carbon; hydrogen / methanol / 1 h

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

4.2: -20 - 20 °C / Inert atmosphere

5.1: sodium hydroxide / methanol; water / 3 h / 60 °C

5.2: pH 1

6.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

6.2: -20 - 20 °C / Inert atmosphere

7.1: 10% palladium on carbon; hydrogen / methanol / 3 h

8.1: methanol / 3 h / 20 °C

8.2: 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 10% palladium on carbon; hydrogen; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1002/ejoc.201100155

Reference yield:

: 1311415-72-1
methyl (S)-3-[2-(tert-butoxycarbonylamino)-3-methylbutoxy]benzoate

: 1311415-86-7
methyl (2S,4R)-4-[3-((S)-2-[(2S,3S)-N,3-dimethyl-2-[(R)-1-methylpiperidine-2-carboxamido]pentanamido]-3-methylbutoxy)benzamido]-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 21 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 °C

3.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -10 - 20 °C / Inert atmosphere

4.1: 10% palladium on carbon; hydrogen / methanol / 1 h

5.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

5.2: -20 - 20 °C / Inert atmosphere

6.1: sodium hydroxide / methanol; water / 3 h / 60 °C

6.2: pH 1

7.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

7.2: -20 - 20 °C / Inert atmosphere

8.1: 10% palladium on carbon; hydrogen / methanol / 3 h

9.1: methanol / 3 h / 20 °C

9.2: 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 10% palladium on carbon; hydrogen; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100155