2-ETHOXYBENZOYLACETONITRILE

Base Information

• Chemical Name: 2-ETHOXYBENZOYLACETONITRILE
• CAS No.: 89-44-1
• Molecular Formula: C11H11 N O2
• Molecular Weight: 189.214
• Mol file: 89-44-1.mol

Synonyms:Acetonitrile,(o-ethoxybenzoyl)- (8CI); (o-Ethoxybenzoyl)acetonitrile

Chemical Property of 2-ETHOXYBENZOYLACETONITRILE

Chemical Property:

• PSA: 50.09000
• LogP: 2.18168

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxybenzoylacetonitrile 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ETHOXYBENZOYLACETONITRILE

There total 3 articles about 2-ETHOXYBENZOYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

ethyl 2-ethoxybenzoate (6290-24-0) + acetonitrile (75-05-8,26809-02-9) → 3-(2-ethoxyphenyl)-3-oxopropanenitrile (89-44-1)

Guidance literature:

With potassium tert-butylate; In toluene; at 0 - 20 ℃; for 1h;

Reference yield:

methyl 2-ethoxybenzoate (3686-55-3) + acetonitrile (75-05-8,26809-02-9) → 3-(2-ethoxyphenyl)-3-oxopropanenitrile (89-44-1)

Guidance literature:

With sodium methylate;

DOI:10.1021/ja01197a004

Reference yield:

→ 3-(2-ethoxyphenyl)-3-oxopropanenitrile (89-44-1)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

methyl 2-ethoxybenzoate

acetonitrile

ethyl 2-ethoxybenzoate

Downstream raw materials:

C₁₃H₁₄N₄O

C₂₅H₃₁N₇O

C₁₄H₁₈N₄O₂

C₂₁H₂₄N₄O₄S

Refernces

• 1、 -. "3-(2-hydroxyphenyl)-5-pyrazolylamidoxime intermediate". Paragraph 0036. . Retrieved 2017/09/02.