tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
CAS No.:920036-43-7
Molecular Formula:C₂₅H₁₈Cl₂F₂N₄O₄
Molecular Weight:547.345
Hs Code.:

Synonyms:tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

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Chemical Property of tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

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Technology Process of tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

There total 1 articles about tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 920036-30-2
tert-butyl 3-(bromomethyl)-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

: 920036-42-6
3-chloro-5-(2-chloro-3-fluoro-5-hydroxyphenoxy)benzonitrile

: 920036-43-7
tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

Guidance literature:: With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 23 ℃; for 2h;
DOI:10.1021/jm901230r

Reference yield: 4.0%

: 920036-43-7
tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

: 2393-23-9
4-methoxy-benzylamine

: 920035-90-1
3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloro-3-fluorophenoxy}-5-chlorobenzonitrile

Guidance literature:: tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 4-methoxy-benzylamine; In 1-methyl-pyrrolidin-2-one; at 95 ℃; for 2h;

With trifluoroacetic acid; at 65 ℃; for 2h;

Reference yield: 4.0%

: 920036-43-7
tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

: 920035-90-1
3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloro-3-fluorophenoxy}-5-chlorobenzonitrile

Guidance literature:: tert-butyl 3-{[4-chloro-3-(3-chloro-5-cyanophenoxy)-5-fluorophenoxy]methyl}-6-fluoro-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; With 4-methoxy-benzylamine; In 1-methyl-pyrrolidin-2-one; at 95 ℃; for 2h; Inert atmosphere;

With trifluoroacetic acid; for 2h;
DOI:10.1021/jm901230r