(3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

Base Information

Chemical Name:(3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine
CAS No.:177945-75-4
Molecular Formula:C₂₄H₂₈N₆
Molecular Weight:400.527
Hs Code.:

Synonyms:(3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

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Chemical Property of (3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

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Technology Process of (3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

There total 11 articles about (3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 177947-99-8
methanesulphonic acid 2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl ester

: 177947-80-7
(3S)-N(H)-3-<(N-benzylamino)methyl>pyrrolidine

: 177945-75-4
(3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

Guidance literature:: With potassium carbonate; In isopropyl alcohol; for 4h; Heating;
DOI:10.1021/jm9805687

Reference yield:

: 99735-47-4
(3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine

: 177945-75-4
(3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / Pearlmans catalyst / methanol; H₂O / 2 h / 2068.59 Torr

2: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 94 percent / toluene / 18 h / Heating

4: 100 percent / 90 percent HCOOH / 18.5 h / Ambient temperature

5: 53 percent / K₂CO₃ / propan-2-ol / 4 h / Heating

With formic acid; hydrogen; potassium carbonate; triethylamine; palladium hydroxide - carbon; In methanol; dichloromethane; water; isopropyl alcohol; toluene;
DOI:10.1021/jm9805687

Reference yield:

: 179636-96-5
(3S)-N-(tert-butyloxycarbonyl)-3-<(N-benzylamino)methyl>pyrrolidine

: 177945-75-4
(3S)-3-(N-benzyl)aminomethyl-1-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 90 percent HCOOH / 18.5 h / Ambient temperature

2: 53 percent / K₂CO₃ / propan-2-ol / 4 h / Heating

With formic acid; potassium carbonate; In isopropyl alcohol;
DOI:10.1021/jm9805687