ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Chemical Name:ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No.:1247019-55-1
Molecular Formula:C₂₂H₁₉FN₂O₆
Molecular Weight:426.401
Hs Code.:

Synonyms:ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 2 articles about ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 940-00-1
(4-methoxyphenyl)trimethylstannane

: 111453-55-5
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 1247019-55-1
ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: With palladium diacetate; cesium fluoride; In N,N-dimethyl-formamide; at 75 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.06.098

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 111453-55-5
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 1247019-55-1
ethyl 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.08.065