3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

Base Information

Chemical Name:3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid
CAS No.:179096-52-7
Molecular Formula:C₃₃H₄₃NO₄Si
Molecular Weight:545.794
Hs Code.:

Synonyms:3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

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Chemical Property of 3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

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Technology Process of 3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

There total 7 articles about 3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 179097-00-8
N-tert-Butyl-N-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-(3-hydroxy-propyl)-5-methyl-benzamide

: 179096-52-7
3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

Guidance literature:: With dipyridinium dichromate; In N,N-dimethyl-formamide; for 17h; Ambient temperature;
DOI:10.1021/jm960092w

Reference yield:

: 4620-70-6
2-[(1,1-dimethylethyl)amino]-ethanol

: 179096-52-7
3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / imidazole / CH₂Cl₂ / 18 h / Ambient temperature

2: Et₃N / tetrahydrofuran

3: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -70 deg C, 1.5 h, 2.) THF, RT, 16 h

4: 27 percent / pyridinum dichromate / dimethylformamide / 17 h / Ambient temperature

With 1H-imidazole; dipyridinium dichromate; sec.-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960092w

Reference yield:

: 22328-43-4
2,5-dimethylbenzoyl chloride

: 179096-52-7
3-(2-{tert-Butyl-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-4-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran

2: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -70 deg C, 1.5 h, 2.) THF, RT, 16 h

3: 27 percent / pyridinum dichromate / dimethylformamide / 17 h / Ambient temperature

With dipyridinium dichromate; sec.-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm960092w