7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

Base Information

Chemical Name:7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane
CAS No.:166896-79-3
Molecular Formula:C₄₂H₇₀O₄Si
Molecular Weight:667.101
Hs Code.:

Synonyms:7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

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Technology Process of 7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

There total 11 articles about 7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 166896-78-2
24-<(tert-Butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholan-7α-ol

: Formic acid (3S,5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

: 166896-79-3
7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

Guidance literature:: With benzyl bromide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.) overnight; 40 deg C, 20 min, 2.) 40 deg C, 10 h;
DOI:10.1021/jo00121a033

Reference yield: 8.0%

: 166896-79-3
7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

Guidance literature:

Reference yield: 1.0%

: 100-39-0
benzyl bromide

: 166896-78-2
24-<(tert-Butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholan-7α-ol

: Formic acid (3S,5R,7R,8R,9S,10S,13R,14S,17R)-17-[(R)-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

: 166896-79-3
7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.) overnight; 40 deg C, 20 min, 2.) 40 deg C, 10 h;
DOI:10.1021/jo00121a033