(2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

Base Information

Chemical Name:(2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide
CAS No.:1297612-61-3
Molecular Formula:C₃₀H₂₂N₆O₂
Molecular Weight:498.544
Hs Code.:

Synonyms:(2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

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Chemical Property of (2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

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Technology Process of (2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

There total 5 articles about (2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 14371-10-9
(E)-3-phenylpropenal

: 1297612-46-4
2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

: 1297612-61-3
(2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

Guidance literature:: With ammonium acetate; acetic acid; at 110 ℃; for 0.0138889h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 1297612-43-1
3-(1-methyl-1H-indol-3-yl)-3-oxo-2-(phenylhydrazono)propanenitrile

: 1297612-61-3
(2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

2: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

3: ammonium acetate; acetic acid / 0.01 h / 110 °C / Microwave irradiation

With hydroxylamine hydrochloride; ammonium acetate; sodium acetate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 343778-74-5
3-(1-methyl-1H-indol-3-yl)-3-oxopropanenitrile

: 1297612-61-3
(2E,4E)-2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-5-phenylpenta-2,4-dienamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 1 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

3.1: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

4.1: ammonium acetate; acetic acid / 0.01 h / 110 °C / Microwave irradiation

With hydrogenchloride; hydroxylamine hydrochloride; ammonium acetate; sodium acetate; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040