2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

Base Information

Chemical Name:2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide
CAS No.:1297612-46-4
Molecular Formula:C₂₁H₁₆N₆O₂
Molecular Weight:384.397
Hs Code.:

Synonyms:2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

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Chemical Property of 2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

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Technology Process of 2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

There total 4 articles about 2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 64992-14-9
acetic 2-cyanoacetic anhydride

: 1205529-59-4
(5-amino-2-phenyl-2H-1,2,3-triazol-4-yl)(1-methyl-1H-indol-3-yl)methanone

: 1297612-46-4
2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

Guidance literature:: at 80 ℃; for 0.00277778h; Microwave irradiation; Neat (no solvent);
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 1297612-43-1
3-(1-methyl-1H-indol-3-yl)-3-oxo-2-(phenylhydrazono)propanenitrile

: 1297612-46-4
2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

2: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

With hydroxylamine hydrochloride; sodium acetate; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 142-04-1,36663-09-9
aniline hydrochloride

: 1297612-46-4
2-cyano-N-[5-(1-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 1 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

3.1: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040