2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

Base Information

Chemical Name:2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin
CAS No.:189157-24-2
Molecular Formula:C₅₁H₈₆FN₅O₁₈
Molecular Weight:1076.26
Hs Code.:

Synonyms:2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

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Chemical Property of 2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

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Technology Process of 2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

There total 4 articles about 2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 189157-23-1
2''-O-acetyl-4'',6''-O-cyclohexylidene-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

: 189157-24-2
2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at -20 ℃; for 6h;
DOI:10.1016/S0008-6215(96)00318-7

Reference yield:

: 933-40-4
cycloxexanone dimethyl ketal

: 189157-24-2
2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / dimethylformamide / 2 h / 50 °C / 30 Torr

2: 98 percent / pyridine / 16 h / Ambient temperature

3: 86 percent / DAST / CH₂Cl₂ / 6 h / -20 °C

With pyridine; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(96)00318-7

Reference yield:

: 78740-48-4
3',4'-dideoxy-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)kanamycin B

: 189157-24-2
2''-O-acetyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)dibekacin

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / dimethylformamide / 2 h / 50 °C / 30 Torr

2: 98 percent / pyridine / 16 h / Ambient temperature

3: 86 percent / DAST / CH₂Cl₂ / 6 h / -20 °C

With pyridine; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(96)00318-7