Benzenesulfonamide, 2-ethyl- (9CI)

Base Information

• Chemical Name: Benzenesulfonamide, 2-ethyl- (9CI)
• CAS No.: 85-92-7
• Molecular Formula: C8H11 N O2 S
• Molecular Weight: 185.247
• Hs Code.: 2935009090
• Mol file: 85-92-7.mol

Synonyms:Benzenesulfonamide,o-ethyl- (6CI,8CI); 2-Ethylbenzenesulfonamide; o-Ethylbenzenesulfonamide

Chemical Property of Benzenesulfonamide, 2-ethyl- (9CI)

Chemical Property:

• PSA: 68.54000
• LogP: 2.67750

Purity/Quality:

99% ^*data from raw suppliers

2-Ethylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenesulfonamide, 2-ethyl- (9CI)

There total 11 articles about Benzenesulfonamide, 2-ethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(tert-butyl)-2-ethylbenzenesulfonamide (769196-04-5) → 2-Ethylbenzenesulfonamide (85-92-7)

Guidance literature:

With trifluoroacetic acid; In ethyl acetate; methoxybenzene; at 0 ℃; for 24h;

DOI:10.1002/hlca.200490148

Reference yield: 92.0%

2-ethylbenzenesulfonyl chloride (34586-43-1) → 2-Ethylbenzenesulfonamide (85-92-7)

Guidance literature:

With ammonia; In tetrahydrofuran; water; at 0 ℃; for 0.1h;

DOI:10.1021/jacs.9b11608

Reference yield: 72.0%

2-ethylbenzenesulfonyl azide (1351416-37-9) → 2-Ethylbenzenesulfonamide (85-92-7) + (S)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide (130973-57-8)

Guidance literature:

With C₃₅H₃₅ClIrN₄O₄; at 20 ℃; for 16h; pH=6;

upstream raw materials:

N-(tert-butyl)-2-ethylbenzenesulfonamide

N-tert-butylbenzenesulfonamide

(2-Ethylphenyl)tributyltin

2-ethylbenzenesulfonyl azide

Downstream raw materials:

2-ethylbenzenesulfonyl azide

(±)-3-methyl-1,2-benzisothiazoline 1,1-dioxide

Refernces

• 1、 Goldberg, Nathaniel W.,Knight, Anders M.,Zhang, Ruijie K.,Arnold, Frances H.. "Nitrene transfer catalyzed by a non-heme iron enzyme and enhanced by non-native small-molecule ligands". . p. 19585 - 19588. Retrieved 2019/12/24.
• 2、 Dydio, Pawel,Key, Hanna M.,Hayashi, Hiroki,Clark, Douglas S.,Hartwig, John F.. "Chemoselective, enzymatic C-H bond amination catalyzed by a cytochrome P450 containing an Ir(Me)-PIX cofactor". supporting information. p. 1750 - 1753. Retrieved 2017/02/15.