benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate

Base Information

• Chemical Name: benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate
• CAS No.: 239789-49-2
• Molecular Formula: C₂₄H₃₇N₃O₆
• Molecular Weight: 463.574
• Mol file: 239789-49-2.mol

Synonyms:benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate

Chemical Property of benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate

There total 7 articles about benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

propionic acid (802294-64-0,79-09-4) + benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino)butyl-1,3-oxazolidine-3-carboxylate (239789-45-8) → benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate (239789-49-2)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1016/S0040-4039(99)00909-0

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) → benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate (239789-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / sodium cyanoborohydride; acetic acid / methanol

2: 59 percent / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 20 °C

With sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jo010456e

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino-2-propionyl)butyl-1,3-oxazolidine-3-carboxylate (239789-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / triethylamine / CHCl₃ / 4 h

2: 35 percent / sodium cyanoborohydride; acetic acid / methanol

3: 59 percent / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; chloroform;

DOI:10.1021/jo010456e

upstream raw materials:

propionic acid

benzyl (R)-2,2-dimethyl-4-(2-aza-4-tert-butoxycarbonylamino)butyl-1,3-oxazolidine-3-carboxylate

di-tert-butyl dicarbonate

N-BOC-1,2-diaminoethane

Downstream raw materials:

(R)-N²-benzyloxycarbonyl-N⁶-tert-butoxycarbonyl-N⁴-propionyl-4-azalysinol