4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester
CAS No.:1331775-94-0
Molecular Formula:C₃₃H₄₉N₃O₆
Molecular Weight:583.769
Hs Code.:

Synonyms:4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331775-93-9
4-hydroxy-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

: 1331775-52-0
3-butyl-6-chloro-4-(4-cyclohexyloxyphenyl)pyridazine

: 1331775-94-0
4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 4-hydroxy-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

3-butyl-6-chloro-4-(4-cyclohexyloxyphenyl)pyridazine; In tetrahydrofuran; for 1h; Reflux;

Reference yield:

: 106-32-1
octanoic acid ethyl ester

: 1331775-94-0
4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate; acetic acid / 12 h / 100 °C

2.1: trichlorophosphate; 2H-Pyridazin-3-one / 0.5 h / 90 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 1 h / Reflux

With 2H-Pyridazin-3-one; sodium hydride; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; mineral oil;

Reference yield:

: 1454-53-1
ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

: 1331775-94-0
4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]-3-methoxymethoxymethylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethyl acetate / 1 h

1.2: 24 h / 2585.81 Torr

2.1: sodium tetrahydroborate / methanol / 0.5 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

4.2: 1 h / Reflux

With sodium tetrahydroborate; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; mineral oil;