1454-53-1

Usage

Uses

Since the provided materials do not specify the uses of Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride, I will provide a general structure for listing its potential applications based on its chemical properties and structure:
Used in Pharmaceutical Industry:
Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride is used as an intermediate compound for the synthesis of various pharmaceuticals, particularly those targeting the central nervous system. Its unique structure allows for the development of drugs with potential applications in treating neurological disorders or as analgesics.
Used in Chemical Research:
In the field of chemical research, Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride can be used as a starting material for the synthesis of more complex organic molecules, including potential candidates for drug development, agrochemicals, or other specialty chemicals.

InChI:InChI=1/C15H19NO3.ClH/c1-2-19-15(18)13-11-16(9-8-14(13)17)10-12-6-4-3-5-7-12;/h3-7,13H,2,8-11H2,1H3;1H

Synthetic route

di-tert-butyl dicarbonate (24424-99-5) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate (98977-34-5)

Conditions	Yield
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With hydrogen; palladium 10% on activated carbon In ethanol at 20℃; under 760.051 Torr; for 15h; Stage #2: di-tert-butyl dicarbonate With triethylamine In ethanol at 20℃; for 16h;	100%
With hydrogen; triethylamine In ethanol	85%
With hydrogen; palladium(II) hydroxide; triethylamine In ethanol under 2585.81 Torr; for 4h;	82%
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium hydrogencarbonate In ethyl acetate for 1h; Stage #2: di-tert-butyl dicarbonate With hydrogen; palladium 10% on activated carbon In ethyl acetate under 2585.81 Torr; for 24h;

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + methylamine (74-89-5) → ethyl 1-benzyl-4-(methylamino)-1,2,5,6-tetrahydropyridine-3- carboxylate

Conditions	Yield
In methanol at 50℃; for 1h; Inert atmosphere;	100%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → ethyl 4-piperidone-3-carboxylate hydrochloride (4644-61-5)

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol; water under 2280 Torr; for 24h; Ambient temperature;	99%
With Pd(OH)2/C; hydrogen In methanol; dichloromethane at 22℃; under 3750.38 Torr; for 48h;	99%
With palladium 10% on activated carbon; hydrogen In ethanol for 7h; Heating;	98.2%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → methyl 4-amino-1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate (70336-83-3)

Conditions	Yield
With ammonium acetate In ethanol at 20℃; for 1h;	99%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 1-acetyl-4-oxo-piperidine-3-carboxylic acid ethyl ester (4451-85-8)

Conditions	Yield
With acetic anhydride In pyridine; ethyl acetate	97%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → C15H21NO3

Conditions	Yield
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium hydroxide In diethyl ether; water at 20℃; Stage #2: In water at 30℃; for 12h;	95%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 4-piperidone-3-carboxylic acid ethyl ester (67848-59-3)

Conditions	Yield
With ammonium formate; palladium on activated charcoal In ethanol for 1h; Heating;	92%
With hydrogen; palladium 10% on activated carbon In ethanol at 20℃; under 3000.3 - 3750.38 Torr; for 3h;

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → C9H14O3NC6H5 (41276-30-6)

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane for 1h;	92%
With sodium hydrogencarbonate In dichloromethane for 1h;	92%
With sodium carbonate In water for 1h;	90%
With sodium hydrogencarbonate In dichloromethane; water

formamidine acetic acid (3473-63-0) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (62458-96-2)

Conditions	Yield
With sodium methylate In methanol for 2h; Heating / reflux;	90%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-2-(2-methoxy-phenyl)-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one (938181-21-6)

Conditions	Yield
Stage #1: 2-Methoxy-benzamidine With sodium methylate In 1,4-dioxane; methanol at 0℃; for 0.25h; Stage #2: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride In 1,4-dioxane; methanol for 2h; Heating / reflux;	87%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → ethyl 1-benzyl-4-hydroxypiperidine-3-carboxylate (956010-25-6)

Conditions	Yield
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With triethylamine In methanol at 20℃; for 0.166667h; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 3h; Stage #3: With hydrogenchloride; methanol; water; sodium hydrogencarbonate more than 3 stages;	84%
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With triethylamine In methanol at 0℃; for 0.166667h; Stage #2: With sodium tetrahydroborate In methanol at 0℃; for 2h;

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → ethyl 1-benzyl-4-(trifluoromethylsulfonyloxy)-1,2,5,6-tetrahydropyridine-3-carboxylate (500732-79-6)

Conditions	Yield
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With potassium carbonate In water Stage #2: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #3: N,N-phenylbistrifluoromethane-sulfonimide In N,N-dimethyl-formamide; mineral oil at 0℃; for 1.5h;	83%
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With potassium carbonate In dichloromethane; water Stage #2: With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #3: N,N-phenylbistrifluoromethane-sulfonimide In N,N-dimethyl-formamide for 1.5h; Inert atmosphere;	83%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + acrylic acid methyl ester (292638-85-8) → 1-benzyl-3-(2-ethoxycarbonyl-ethyl)-4-oxo-piperidine-3-carboxylic acid ethyl ester (1421131-30-7)

Conditions	Yield
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With caesium carbonate In acetone Reflux; Stage #2: acrylic acid methyl ester In acetone for 3.5h; Reflux;	81%

formamidine hydrochloride (6313-33-3) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (109229-22-3)

Conditions	Yield
With sodium methylate In methanol at 85℃;	77%

6-acetoxy-2,3-dihydrobenzofuran (85878-59-7) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 3-Benzyl-1,2,3,4,9,10-hexahydro-6,8-dioxa-3-aza-cyclopenta[b]phenanthren-5-one; hydrochloride (88701-60-4)

Conditions	Yield
With hydrogenchloride In acetic acid for 120h; Ambient temperature;	75%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + 6-acetoxy-7-methyl-2,3-dihydrobenzofuran (21861-24-5) → 3-Benzyl-7-methyl-1,2,3,4,9,10-hexahydro-6,8-dioxa-3-aza-cyclopenta[b]phenanthren-5-one; hydrochloride (88701-61-5)

Conditions	Yield
With hydrogenchloride In acetic acid for 120h; Ambient temperature;	75%

2-chloroacetamidine hydrochloride (10300-69-3) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 7-benzyl-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4(3H)-one (859825-10-8)

Conditions	Yield
With sodium methylate In methanol at 100℃; for 0.25h; Microwave irradiation;	72%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + urea (57-13-6) → 5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione (135481-57-1)

Conditions	Yield
With sodium methylate In ethanol for 24h; Heating / reflux;	70%
With sodium methylate In methanol at 0℃; for 40h; Reflux;	60%
With sodium methylate In methanol at 0 - 60℃; for 20h; Inert atmosphere;	42%

formamidine acetic acid (3473-63-0) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (109229-22-3)

Conditions	Yield
Stage #1: formamidine acetic acid; ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium methylate In methanol at 85℃; for 16h; in sealed vessel; Stage #2: With sodium hydroxide In water at 0℃; Stage #3: With acetic acid In water pH=7;	61.4%
Stage #1: formamidine acetic acid; ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium methylate In methanol at 85℃; for 16h; Stage #2: With sodium hydroxide In water Stage #3: With acetic acid In water at 0℃; pH=7;	61.4%
Stage #1: formamidine acetic acid; ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium methylate In methanol at 85℃; for 16h; Stage #2: With sodium hydroxide In water Cooling with ice; Stage #3: With acetic acid In water pH=7;	61.4%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → (3RS,4RS)-1-benzyl-3-hydroxymethyl-piperidin-4-ol (886-46-4)

Conditions	Yield
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium hydroxide; water In methanol at 20℃; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃;	61%
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride With sodium tetrahydroborate; sodium hydroxide In methanol at 0℃; for 0.5h; Stage #2: With lithium aluminium tetrahydride In diethyl ether at 0℃; for 1h;

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + 3-methyl-phenol (108-39-4) → 1,2,3,4-tetrahydro-8-methyl-3-(phenylmethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one (193217-46-8)

Conditions	Yield
	60%

S-methylthiouronium iodide (4338-95-8) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-2-methylthio-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (1033-34-7)

Conditions	Yield
With potassium carbonate In water at 60℃; for 12h;	59%

acetamidine hydrochloride (124-42-5) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 6-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (1448-40-4)

Conditions	Yield
With potassium carbonate In methanol; water at 60℃; for 16h;	55%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 5-benzyl-3-ethoxy-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (1207678-58-7) + 5-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3(2H)-one hydrochloride

Conditions	Yield
With hydrazine hydrochloride In ethanol for 8h; Reflux;	A 38% B 52%

Isobutyl iodide (513-38-2) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → ethyl 1-benzyl-3-isobutyl-4-oxopiperidine-3-carboxylate

Conditions	Yield
With potassium tert-butylate In isopropyl alcohol at 20 - 75℃; for 12.33h;	48%

3,4-dimethoxyphenol (2033-89-8) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 3-Benzyl-8,9-dimethoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one

Conditions	Yield
	40%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + 2-hydrazinyl-5-methyl-1H-benzo[d]imidazole (93102-21-7) → 5-benzyl-2-(5-methyl-1H-benzo[d]imidazol-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo-[4,3-c]pyridin-3-ol

Conditions	Yield
With acetic acid at 20℃; for 12h;	37%

2,3-dihydro-4-hydroxybenzofuran (144822-82-2) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 2-benzyl-1,2,3,4,8,9-hexahydro-11H-furo<3',2':7,8><1>benzopyrano<3,4-c>pyridin-11-one (144822-83-3)

Conditions	Yield
With sulfuric acid; trichlorophosphate Ambient temperature;	30%

2-methylbenzene-1,4-diol (95-71-6) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 3-Benzyl-9-hydroxy-8-methyl-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one hydrochloride

Conditions	Yield
	28%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + 5-(phenoxymethyl)-2-amino-2-oxazoline (32968-43-7) → 7-benzyl-2-(phenoxymethyl)-1,2,6,7,8,9-hexahydro-5H-[1,3]oxazolo[3,2-a]pyrido[3,4-e]pyrimidin-5-one + 7-benzyl-2-(phenoxymethyl)-2,3,6,7,8,9-hexahydro-5H-[1,3]oxazolo[3,2-a]pyrido[4,3-d]pyrimidin-5-one

Conditions	Yield
With potassium carbonate In ethanol; water at 25℃; for 48h; cyclocondensation;	A 26% B 12%

Downstream Products

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 21875-55-8 4,4-diethoxy-1-benzyl-piperidine; hydrochloride 
• 27296-60-2 3-benzyl-10-hydroxy-8-methyl-1,2,3,4-tetrahydropyrido<3,4-c>coumarin 
• 777791-00-1 3-benzyl-8-(1,2-dimethyl-heptyl)-10-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one 
• 144822-84-4 3-Benzyl-10-(4-hydroxy-2,3-dihydro-benzofuran-5-yl)-1,2,3,4,5,10,15,16-octahydro-7,17-dioxa-3-aza-cyclopenta[a]phenanthren-6-one 
• 144822-83-3 2-benzyl-1,2,3,4,8,9-hexahydro-11H-furo<3',2':7,8><1>benzopyrano<3,4-c>pyridin-11-one 
• 75929-32-7 3-benzyl-8,10-dihydroxy-1,2,3,4-tetrahydropyrido<3,4-c>coumarin hydrochloride 
• 88701-60-4 3-Benzyl-1,2,3,4,9,10-hexahydro-6,8-dioxa-3-aza-cyclopenta[b]phenanthren-5-one; hydrochloride 
• 88701-61-5 3-Benzyl-7-methyl-1,2,3,4,9,10-hexahydro-6,8-dioxa-3-aza-cyclopenta[b]phenanthren-5-one; hydrochloride 
• 4644-61-5 ethyl 4-piperidone-3-carboxylate hydrochloride 
• 75929-31-6 3-benzyl-10-hydroxy-1,2,3,4-tetrahydropyrido<3,4-c>coumarin 
• 86371-02-0 1,2,3,4-Tetrahydro-8-hydroxy-3-(phenylmethyl)-5H-<1>benzopyrano<3,4-c>pyridin-5-one 
• 127956-04-1 ethyl 1-benzyl-3-methyl-4-oxopiperidine-3-carboxylate 
• 859825-10-8 7-benzyl-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4(3H)-one