1-(5-bromopyridin-2-yl)-1H-benzimidazole

Base Information

• Chemical Name: 1-(5-bromopyridin-2-yl)-1H-benzimidazole
• CAS No.: 1043906-08-6
• Molecular Formula: C₁₂H₈BrN₃
• Molecular Weight: 274.12
• Mol file: 1043906-08-6.mol

Synonyms:1-(5-bromopyridin-2-yl)-1H-benzo[d]imidazole

Chemical Property of 1-(5-bromopyridin-2-yl)-1H-benzimidazole

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(5-bromopyridin-2-yl)-1H-benzimidazole

There total 2 articles about 1-(5-bromopyridin-2-yl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzoimidazole (51-17-2,79351-71-6) + 5-bromo-2-fluoropyridine (766-11-0) → 1-(5-bromopyridin-2-yl)-1H-benzo[d]imidazole (1043906-08-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5ra18653f

Reference yield: 90.0%

benzoimidazole (51-17-2,79351-71-6) + 2-iodo-5-bromopyridine (223463-13-6) → 1-(5-bromopyridin-2-yl)-1H-benzo[d]imidazole (1043906-08-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200800018

Reference yield: 96.0%

1-(5-bromopyridin-2-yl)-1H-benzo[d]imidazole (1043906-08-6) + 2-Methoxyphenylboronic acid (5720-06-9) → C19H15N3O (1043906-13-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.200800018

upstream raw materials:

benzoimidazole

2-iodo-5-bromopyridine

5-bromo-2-fluoropyridine

Downstream raw materials:

C₁₉H₁₅N₃O

C₁₉H₁₅N₃O

5-bromo-2-(1H-pyrazol-1-yl)pyridine

Refernces

• 1、 Wang, Lei,Liu, Ning,Dai, Bin. "Metal-free site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines". . p. 82097 - 82111. Retrieved 2015/10/12.