15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester

Base Information

• Chemical Name: 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester
• CAS No.: 791805-08-8
• Molecular Formula: C₅₇H₈₉NO₈
• Molecular Weight: 916.336
• Mol file: 791805-08-8.mol

Synonyms:15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester

Chemical Property of 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester

There total 4 articles about 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N,N-[bis(2-hydroxyethyl)]-N-(triphenylmethyl)amine (23202-47-3) + 15-chloromethoxy-pentadecanoic acid methyl ester (791805-04-4) → 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester (791805-08-8)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jo0493020

Reference yield:

pentadecanolide (106-02-5,81031-90-5) → 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester (791805-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / Amberlyst A-15 / 48 h / Heating

2: chlorotrimethylsilane / CH₂Cl₂ / 1.33 h / 20 °C

3: 82 percent / diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / 6 h / Heating

With chloro-trimethyl-silane; Amberlyst A-15; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0493020

Reference yield:

methyl 15-hydroxypentadecanoate (76529-42-5) → 15-(2-{[2-(13-methoxycarbonyl-tridecyloxymethoxy)-ethyl]-trityl-amino}-ethoxy-methoxy)-pentadecanoic acid methyl ester (791805-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorotrimethylsilane / CH₂Cl₂ / 1.33 h / 20 °C

2: 82 percent / diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / 6 h / Heating

With chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0493020

upstream raw materials:

N,N-[bis(2-hydroxyethyl)]-N-(triphenylmethyl)amine

15-chloromethoxy-pentadecanoic acid methyl ester

pentadecanolide

methyl 15-hydroxypentadecanoate

Downstream raw materials:

C₇₄H₁₂₂N₂O₁₀

bis-(2-(15-allyloxy-pentadecyloxymethoxy)-ethyl)-trityl-amine

C₅₉H₉₅NO₇

bis(2-(15-iodo-pentadecyloxymethoxy)-ethyl)-trityl-amine