4-(3,4-Dichlorophenyl)piperidin-4-ol

Base Information

• Chemical Name: 4-(3,4-Dichlorophenyl)piperidin-4-ol
• CAS No.: 21928-32-5
• Molecular Formula: C₁₁H₁₃Cl₂NO
• Molecular Weight: 246.136
• DSSTox Substance ID: DTXSID40595506
• Wikidata: Q82490520
• Mol file: 21928-32-5.mol

Synonyms:4-(3,4-dichlorophenyl)piperidin-4-ol;4-(3,4-DICHLOROPHENYL)-4-PIPERIDINOL;21928-32-5;SCHEMBL654759;DTXSID40595506;TQR1250;CHFUSNXDQCWMGF-UHFFFAOYSA-N;AKOS012081601;4-hydroxy-4-(3,4-dichlorophenyl)piperidine

Chemical Property of 4-(3,4-Dichlorophenyl)piperidin-4-ol

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 245.0374194
• Heavy Atom Count: 15
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

4-(3,4-Dichlorophenyl)-4-piperidinolHCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1(C2=CC(=C(C=C2)Cl)Cl)O

Technology Process of 4-(3,4-Dichlorophenyl)piperidin-4-ol

There total 5 articles about 4-(3,4-Dichlorophenyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(3,4-dichloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (256958-81-3) → 4-(3,4-dichlorophenyl)-4-hydroxypiperidine (21928-32-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.9b00864

Reference yield: 90.0%

→ 4-(3,4-dichlorophenyl)-4-hydroxypiperidine (21928-32-5)

Guidance literature:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(3,4-dichlorophenyl)-4-hydroxypiperidine (21928-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.5 h / 0 °C / Reflux

2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With trifluoroacetic acid; In dichloromethane;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

3,4-dichlorophenylmagnesium bromide

4-(3,4-dichloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

4-bromo-1,2-dichlorobenzene

Downstream raw materials:

1-[3-{4-(3,4-dichlorophenyl)-1,2,5,6-tetrahydropyridin-1-yl}-propylcarbamoyl]-2-oxopyrrolidine

C₁₉H₂₆Cl₂N₂O₃

4-(4-(3,4-dichlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one