(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

Base Information

Chemical Name:(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid
CAS No.:1073543-66-4
Molecular Formula:C₃₀H₃₁FO₄
Molecular Weight:474.572
Hs Code.:

Synonyms:(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

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Chemical Property of (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

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Technology Process of (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

There total 6 articles about (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1073545-20-6
methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

: 1073543-66-4
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

Guidance literature:: methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate; With lithium hydroxide; ethanol; water; In tetrahydrofuran; at 23 ℃; for 16h;

With hydrogenchloride; water; In tetrahydrofuran; pH=1;

Reference yield:

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 1073543-66-4
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3.1: thionyl chloride / dichloromethane / 16 h / 23 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 22 h / 23 °C

5.1: lithium hydroxide; ethanol; water / tetrahydrofuran / 16 h / 23 °C

5.2: pH 1

With lithium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1073543-66-4
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3.1: thionyl chloride / dichloromethane / 16 h / 23 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 22 h / 23 °C

5.1: lithium hydroxide; ethanol; water / tetrahydrofuran / 16 h / 23 °C

5.2: pH 1

With lithium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;