methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

Base Information

Chemical Name:methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate
CAS No.:1073545-20-6
Molecular Formula:C₃₁H₃₃FO₄
Molecular Weight:488.599
Hs Code.:

Synonyms:methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

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Chemical Property of methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

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Technology Process of methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

There total 5 articles about methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 865233-36-9
(3S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid methyl ester

: 1073544-88-3
5-(chloromethyl)-2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

: 1073545-20-6
methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 22h;

Reference yield:

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 1073545-20-6
methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3: thionyl chloride / dichloromethane / 16 h / 23 °C

4: caesium carbonate / N,N-dimethyl-formamide / 22 h / 23 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1073545-20-6
methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexynoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3: thionyl chloride / dichloromethane / 16 h / 23 °C

4: caesium carbonate / N,N-dimethyl-formamide / 22 h / 23 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;