4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile

Base Information

• Chemical Name: 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile
• CAS No.: 940959-04-6
• Molecular Formula: C₁₆H₉F₃N₄
• Molecular Weight: 314.269
• Mol file: 940959-04-6.mol

Synonyms:4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile

Chemical Property of 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile

There total 2 articles about 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

4,4,4-trifluoro-1-(pyridin-3-yl)butane-1,3-dione (582-73-0) + 4-hydrazinobenzonitrile (17672-27-4) → 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile (940959-04-6) + 4-(5-hydroxy-3-pyridin-3-yl-5-trifluorom,ethyl-4,5-dihydro-pyrazol-1-yl)-benzonitrile (940959-03-5)

Guidance literature:

With acetic acid; In ethanol; for 16h; Heating / reflux;

Reference yield:

4,4,4-trifluoro-1-(pyridin-3-yl)butane-1,3-dione (582-73-0) + 4-hydrazinobenzonitrile (17672-27-4) → 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile (940959-04-6) + 4-(3-pyridin-3-yl-5-trifluoromethyl-pyrazol-1-yl)-benzonitrile (940959-05-7)

Guidance literature:

4,4,4-trifluoro-1-(pyridin-3-yl)butane-1,3-dione; 4-hydrazinobenzonitrile; In ethanol; Reflux;

With acetic acid; at 100 ℃;

DOI:10.1016/j.bmcl.2010.09.095

Reference yield: 49.0%

4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile (940959-04-6) → 4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzylamine

Guidance literature:

4-(5-pyridin-3-yl-3-trifluoromethyl-pyrazol-1-yl)-benzonitrile; With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 4h;

With sodium hydroxide; water; In diethyl ether; for 0.25h;

upstream raw materials:

4,4,4-trifluoro-1-(pyridin-3-yl)butane-1,3-dione

4-hydrazinobenzonitrile