butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

Base Information

Chemical Name:butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate
CAS No.:1075237-62-5
Molecular Formula:C₁₈H₂₈N₂O₄
Molecular Weight:336.431
Hs Code.:

Synonyms:butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

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Chemical Property of butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

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Technology Process of butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

There total 1 articles about butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17920-35-3
2-amino-6-methoxypyridine

: 1075237-62-5
butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: [Cp*RhCl₂]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 36 h / 120 °C / Schlenk technique; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr

With dmap; silver hexafluoroantimonate; [Cp*RhCl₂]2; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol401540k

Reference yield:

: 1075237-62-5
butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

: 1075238-03-7
phenylmethyl (1-{[(2R)-4,9-dioxo-1,2,8,9-tetrahydro-4H,7H-imidazo[1,2,3-ij]-1,8-naphthyridin-2-yl]methyl}-4-methyl-4-piperidinyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water / 6 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 6 h / 120 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: pyridine / acetonitrile / 6 h / Heating / reflux

With pyridine; hydrogenchloride; water; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1075237-62-5
butyl 3-[2-[(2,2-dimethylpropanoyl)amino]-6-(methyloxy)-3-pyridinyl]propanoate

: (1R)-1-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione dihydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / 6 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 6 h / 120 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: pyridine / acetonitrile / 24 h / 70 °C / Heating / reflux

6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 2 h / 20 - 120 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol; chloroform / 0.5 h / 20 °C

With pyridine; hydrogenchloride; water; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;