4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

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Chemical Name:4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one
CAS No.:1357192-67-6
Molecular Formula:C₂₇H₂₆FN₅O₃
Molecular Weight:487.534
Hs Code.:

Synonyms:4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

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Chemical Property of 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

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Technology Process of 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

There total 9 articles about 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 4-fluoro-1-isopropyl-5-{2-[3-methoxy-2-oxo-1-(1-phenyl-1H-pyrazol-5-yl)propylidene]hydrazino}-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1357192-67-6
4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: In acetonitrile; Reflux;
DOI:10.1016/j.bmc.2015.10.002

Reference yield:

: 866211-50-9
4-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

: 1357192-67-6
4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; sulfuric acid / 0.5 h / -30 - 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C

4.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

4.2: 0 °C

5.1: acetonitrile / Reflux

With hydrogenchloride; sulfuric acid; 5%-palladium/activated carbon; hydrogen; nitric acid; sodium hydride; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2015.10.002

Reference yield:

: 1357192-10-9
4-fluoro-3,3-dimethyl-5-nitro-1,3-dihydro-2H-indol-2-one

: 1357192-67-6
4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(1-methylethyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

3.2: 0 °C

4.1: acetonitrile / Reflux

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; sodium hydride; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2015.10.002