allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine

Base Information

• Chemical Name: allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine
• CAS No.: 644994-57-0
• Molecular Formula: C₁₇H₁₅BrCl₂N₄
• Molecular Weight: 426.143

Synonyms:allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine

Chemical Property of allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine

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Technology Process of allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine

There total 4 articles about allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-methyl-N-allylamine (627-37-2) + 5-bromo-4-chloro-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (644994-55-8) → allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine (644994-57-0)

Guidance literature:

With toluene-4-sulfonic acid; Heating;

DOI:10.3987/COM-03-S(P)41

Reference yield:

5-Allyl-2-methyl-4,6-dichloropyrimidine (85826-33-1) → allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine (644994-57-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 37 percent / NaH / dimethylformamide

2.1: osmium tetroxide; sodium periodate / acetone; H₂O

2.2: 53 percent / aq. HCl / CH₂Cl₂

3.1: 100 percent / Br₂ / dioxane

4.1: 60 percent / TsOH / Heating

With sodium periodate; osmium(VIII) oxide; bromine; sodium hydride; toluene-4-sulfonic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;

DOI:10.3987/COM-03-S(P)41

Reference yield:

4-Chloro-1-(2,4-dichlorophenyl)-6-methyl-5,7-diazaindole (268547-64-4) → allyl-[5-bromo-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine (644994-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Br₂ / dioxane

2: 60 percent / TsOH / Heating

With bromine; toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.3987/COM-03-S(P)41

upstream raw materials:

N-methyl-N-allylamine

5-bromo-4-chloro-7-(2,4-dichloro-phenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine

5-Allyl-2-methyl-4,6-dichloropyrimidine

4-Chloro-1-(2,4-dichlorophenyl)-6-methyl-5,7-diazaindole

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