(S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester
• CAS No.: 162473-71-4
• Molecular Formula: C₁₅H₂₂O₄
• Molecular Weight: 266.337
• Mol file: 162473-71-4.mol

Synonyms:(S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester

Chemical Property of (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester

There total 3 articles about (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester (162473-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 1N aq. H₂SO₄, NaNO₂

2: diethyl ether

3: TfOH / diethyl ether

With trifluorormethanesulfonic acid; sulfuric acid; sodium nitrite; In diethyl ether;

DOI:10.1248/cpb.42.2394

Reference yield:

(S)-2-hydroxyl-3,3-dimethylbutyric acid (13748-90-8,498-36-2) → (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester (162473-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: TfOH / diethyl ether

With trifluorormethanesulfonic acid; In diethyl ether;

DOI:10.1248/cpb.42.2394

Reference yield:

methyl (2S)-2-hydroxy-4-methylpentanoate (17392-84-6) + O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → (S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid methyl ester (162473-71-4)

Guidance literature:

With trifluorormethanesulfonic acid; In diethyl ether; Yield given;

DOI:10.1248/cpb.42.2394

upstream raw materials:

methyl (2S)-2-hydroxy-4-methylpentanoate

O-(4-methoxybenzyl)-trichloroacetimidate

L-leucine

(S)-2-hydroxyl-3,3-dimethylbutyric acid

Downstream raw materials:

(S)-2-(4-methoxybenzyloxy)-4-methylpentanoic acid

(S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoyl chloride

desepoxyarenastatin A

(S)-2-(4-Methoxy-benzyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-4-phenyl-but-3-enyl ester