O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester

Base Information

• Chemical Name: O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester
• CAS No.: 70900-87-7
• Molecular Formula: C₄₂H₃₉N₂O₇PS₂
• Molecular Weight: 778.887
• Mol file: 70900-87-7.mol

Synonyms:O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester

Chemical Property of O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester

There total 2 articles about O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) + 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine (42926-80-7) → O5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester (70900-87-7)

Guidance literature:

With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; Yield given. Multistep reaction; 1.) RT, 30 min, 2.) RT, 20 min;

DOI:10.1246/bcsj.54.3815

Reference yield:

→ O5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester (70900-87-7)

Guidance literature:

Phosphordithioat 1a, Thymidinderivat 2;

DOI:10.1021/jo01327a077

Reference yield: 86.0%

O5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester (70900-87-7) → Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester (56883-49-9)

Guidance literature:

With pyridine; pyridinium salt of phosphonic acid; at 30 ℃; for 15h;

DOI:10.1246/bcsj.54.3815

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

Downstream raw materials:

Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

C₃₆H₃₄N₂O₈PS^(1-)*Na⁽¹⁺⁾

C₁₆H₁₈N₂O₇PS^(1-)*Na⁽¹⁺⁾