3H-Indole,6-chloro-(9CI)

Base Information

• Chemical Name: 3H-Indole,6-chloro-(9CI)
• CAS No.: 754156-53-1
• Molecular Formula: C₈H₆ClN
• Molecular Weight: 151.595
• Mol file: 754156-53-1.mol

Synonyms:3H-Indole,6-chloro-(9CI)

Chemical Property of 3H-Indole,6-chloro-(9CI)

Chemical Property:

• PSA: 12.36000
• LogP: 2.03400

Purity/Quality:

99%min ^*data from raw suppliers

6-Chloro-3H-indole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Indole,6-chloro-(9CI)

There total 3 articles about 3H-Indole,6-chloro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-chlorophenyl)ethenesulfinamide (181651-03-6) → 4-chloro-1H-indole (740058-59-7) + 6-chloro-1H-indole (754156-53-1)

Guidance literature:

With Trimethyl borate; In toluene; at 85 ℃; for 1h; Title compound not separated from byproducts;

Reference yield:

3-chloro-N-sulfinyl-aniline (15851-82-8) → 6-chloro-1H-indole (754156-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / tetrahydrofuran / 2 h / -78 deg C to room temp.

2: B(OCH₃)3 / toluene / 1 h / 85 °C

With Trimethyl borate; In tetrahydrofuran; toluene;

Reference yield:

3-chloro-aniline (108-42-9) → 6-chloro-1H-indole (754156-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / benzene / 4 h / Heating

2: 96 percent / tetrahydrofuran / 2 h / -78 deg C to room temp.

3: B(OCH₃)3 / toluene / 1 h / 85 °C

With thionyl chloride; Trimethyl borate; In tetrahydrofuran; toluene; benzene;

upstream raw materials:

N-(3-chlorophenyl)ethenesulfinamide

3-chloro-N-sulfinyl-aniline

3-chloro-aniline

Refernces