(R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

Base Information

Chemical Name:(R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester
CAS No.:1050392-38-5
Molecular Formula:C₁₈H₂₄FNO₅
Molecular Weight:353.391
Hs Code.:

Synonyms:(R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

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Chemical Property of (R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

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Technology Process of (R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

There total 3 articles about (R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1050392-38-5
(R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

With triethylamine; dmap; In tetrahydrofuran;

Reference yield:

: 144978-12-1,128811-48-3,144978-35-8,251924-83-1
1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate

: 352-13-6
4-flourophenylmagnesium bromide

: 1050392-38-5
(R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

Guidance literature:: 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at -40 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1050392-38-5
(R)-2-t-butoxycarbonylamino-5-(4-fluorophenyl)-5-oxovaleric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

With triethylamine; dmap; In tetrahydrofuran;