{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

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Chemical Name:{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid
CAS No.:151294-49-4
Molecular Formula:C₂₆H₃₈N₂O₇Si
Molecular Weight:518.682
Hs Code.:

{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

Synonyms:{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

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Chemical Property of {(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

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Technology Process of {(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

There total 5 articles about {(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 151294-48-3
{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetaldehyde

: 151294-49-4
{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; for 2.5h; Ambient temperature;

Reference yield:

: 120232-08-8
5'-O-(tert-butyldimethylsilyl)-3'-C-allyl-2',3'-dideoxythymidine

: 151294-49-4
{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Ph₃P, diethyl azodicarboxylate / dioxane / 8 h / Ambient temperature

2: OsO₄, H₂O / dioxane / 0.25 h / Ambient temperature

3: aq. NaIO₄ / dioxane / 24 h / 20 - 25 °C

4: 100 percent / 2-methylbut-2-ene, sodium chlorite, aq. NaH₂PO₄ / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; water; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; tert-butyl alcohol;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 151294-49-4
{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Ph₃P, diethyl azodicarboxylate / dioxane / 8 h / Ambient temperature

2: OsO₄, H₂O / dioxane / 0.25 h / Ambient temperature

3: aq. NaIO₄ / dioxane / 24 h / 20 - 25 °C

4: 100 percent / 2-methylbut-2-ene, sodium chlorite, aq. NaH₂PO₄ / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; water; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; tert-butyl alcohol;