(E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

Base Information

Chemical Name:(E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide
CAS No.:1440434-19-4
Molecular Formula:C₁₉H₁₈N₂O₅
Molecular Weight:354.362
Hs Code.:

Synonyms:(E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

Suppliers and Price of (E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

Chemical Property:

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Technology Process of (E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

There total 4 articles about (E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1440434-15-0
C₁₀H₁₂N₂O₂

: 77201-71-9
(E)-3-(3,4-dihydroxyphenyl)acryloyl chloride

: 1440434-19-4
(E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2013.04.033

Reference yield:

: 331-39-5,501-16-6
caffeic acid

: 1440434-19-4
(E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / Cooling with ice

2: sodium hydrogencarbonate / tetrahydrofuran; water / 4 h / 20 °C

With oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.04.033

Reference yield:

: 99-57-0
2-hydroxy-5-nitroaniline

: 1440434-19-4
(E)-N-(5-(3-(3,4-dihydroxyphenyl)acrylamido)-2-hydroxyphenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C / Cooling with ice

2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 4 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2013.04.033