Technology Process of (R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-(phenylamino)propyl)butanamide
There total 6 articles about (R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-(phenylamino)propyl)butanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: camphor-10-sulfonic acid / N,N-dimethyl-formamide / 16 h / 20 °C
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation
3: acetic acid; water / 16 h / 20 °C
With
camphor-10-sulfonic acid; water; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.04.030
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation
2: acetic acid; water / 16 h / 20 °C
With
water; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.04.030
