(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one
CAS No.:1472660-06-2
Molecular Formula:C₂₁H₂₇NO₅
Molecular Weight:373.449
Hs Code.:

Synonyms:(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

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Chemical Property of (4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

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Technology Process of (4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

There total 3 articles about (4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-(S)-3-(1,4-Dioxa-spiro[4.5]dec-2-yl)-acrylic acid ethyl ester

: 1472660-06-2
(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

2: water; lithium hydroxide / methanol; tetrahydrofuran / 10 h

3: triethylamine / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

4: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; water; triethylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201200519

Reference yield:

: 726193-03-9
(S)-ethyl 3-(1,4-dioxaspiro[4.5]decan-2-yl)propanoate

: 1472660-06-2
(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / methanol; tetrahydrofuran / 10 h

2: triethylamine / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

3: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

With water; triethylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201200519

Reference yield:

: 1472660-04-0
3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoic acid

: 1472660-06-2
(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

2: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

With triethylamine; lithium chloride; In tetrahydrofuran;
DOI:10.1002/hlca.201200519