(4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one
CAS No.:1472660-08-4
Molecular Formula:C₂₂H₂₉NO₅
Molecular Weight:387.476
Hs Code.:

Synonyms:(4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

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Chemical Property of (4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

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Technology Process of (4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

There total 5 articles about (4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1472660-06-2
(4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one

: 74-88-4
methyl iodide

: 1472660-08-4
(4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

Guidance literature:: (4R)-4-benzyl-3-{3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoyl}-1,3-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1002/hlca.201200519

Reference yield:

: (E)-(S)-3-(1,4-Dioxa-spiro[4.5]dec-2-yl)-acrylic acid ethyl ester

: 1472660-08-4
(4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

2.1: water; lithium hydroxide / methanol; tetrahydrofuran / 10 h

3.1: triethylamine / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

4.1: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 3 h / -78 °C / Inert atmosphere

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; water; sodium hexamethyldisilazane; triethylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201200519

Reference yield:

: C₁₆H₂₆O₅

: 1472660-08-4
(4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

With sodium hexamethyldisilazane; lithium chloride; In tetrahydrofuran;
DOI:10.1002/hlca.201200519