(R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
• CAS No.: 1197420-05-5
• Molecular Formula: C₂₄H₂₁ClN₂O₄S
• Molecular Weight: 468.961

Synonyms:(R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property of (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

There total 10 articles about (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

(R)-2-(4-amino-2-methoxyphenoxy)-1-cyclopropylethanol (1197420-19-1) + (E)-Methyl 5-(4-chlorophenyl)-3-(2-(dimethylamino)vinyl)thiophene-2-carboxylate (1197420-20-4) → (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (1197420-05-5)

Guidance literature:

In phenol; at 130 ℃; for 0.5h;

Reference yield: 74.2%

methyl 5-(4-chlorophenyl)-3-{[(1E)-(dimethylamino)methylidene]amino}-2-thiophenecarboxylate (515141-52-3) + (R)-2-(4-amino-2-methoxyphenoxy)-1-cyclopropylethanol (1197420-19-1) → (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (1197420-05-5)

Guidance literature:

In phenol; at 130 ℃; for 0.5h;

DOI:10.1021/jm500026w

Reference yield: 73.0%

(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate (1197420-26-0) → (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (1197420-05-5) + BMS830216 (1197420-06-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -2 - 1 ℃;

upstream raw materials:

(R)-2-(4-amino-2-methoxyphenoxy)-1-cyclopropylethanol

(E)-Methyl 5-(4-chlorophenyl)-3-(2-(dimethylamino)vinyl)thiophene-2-carboxylate

(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

2-bromo-1-cyclopropylethan-1-one

Downstream raw materials:

(R)-5-(2-(4-(6-(4-Chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethoxy)-5-oxopentanoic acid

C₃₁H₃₂ClN₃O₇S

(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

C₃₄H₃₈ClN₃O₇S

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