cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Base Information

Chemical Name:cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine
CAS No.:1310743-81-7
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

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Chemical Property of cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

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Technology Process of cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

There total 6 articles about cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1310743-78-2
cis-N-benzyl-3-methoxy-3,4-dihydrospiro-[[2]benzopyran-1,1`-cyclohexan]-4`-amine

: 1310743-81-7
cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; water; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.002

Reference yield:

: 1310743-77-1
3-methoxy-3,4-dihydrospiro[[2]benzopyran-1,1'-cyclohexan]-4'-one

: 1310743-81-7
cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane; water / 3 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2011.04.002

Reference yield:

: 112396-13-1
2-(2-bromophenyl)acetaldehyde dimethyl acetal

: 1310743-81-7
cis-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / chloroform; water / 1.33 h / 20 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform; water;
DOI:10.1016/j.bmc.2011.04.002