N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
• CAS No.: 1441720-56-4
• Molecular Formula: C₁₄H₁₅F₃N₄O₃S
• Molecular Weight: 376.359
• Mol file: 1441720-56-4.mol

Synonyms:N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Chemical Property of N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

There total 4 articles about N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine (515824-43-8) + 2-methoxy-4-(methylsulfonyl)aniline (41608-73-5) → N2-(2-methoxy-4-(methylsulfonyl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1441720-56-4)

Guidance literature:

With trifluoroacetic acid; In butan-1-ol; at 100 ℃; for 1.5h; Sealed tube;

Reference yield:

2-methoxy-4-(methylsulfanyl)-1-nitrobenzene (860734-15-2) → N2-(2-methoxy-4-(methylsulfonyl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1441720-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Oxone / methanol; acetone; water / 2.25 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 760.05 Torr

3: trifluoroacetic acid / butan-1-ol / 1.5 h / 100 °C / Sealed tube

With Oxone; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; ethanol; water; acetone; butan-1-ol;

Reference yield:

4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) → N2-(2-methoxy-4-(methylsulfonyl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1441720-56-4)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 18 h / 20 °C

2: Oxone / methanol; acetone; water / 2.25 h / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 760.05 Torr

4: trifluoroacetic acid / butan-1-ol / 1.5 h / 100 °C / Sealed tube

With Oxone; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone; butan-1-ol;

upstream raw materials:

2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine

2-methoxy-4-(methylsulfonyl)aniline

2-methoxy-4-(methylsulfanyl)-1-nitrobenzene

4-fluoro-2-methoxy-1-nitrobenzene