(4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one
CAS No.:479202-78-3
Molecular Formula:C₂₁H₂₉NO₅
Molecular Weight:375.465
Hs Code.:

Synonyms:(4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

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Chemical Property of (4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

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Technology Process of (4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

There total 3 articles about (4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 107-30-2
chloromethyl methyl ether

: 479202-77-2
(4R,5S)-3-[(2S,3S,4S)-3-hydroxy-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

: 479202-78-3
(4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 19h;
DOI:10.1055/s-2002-34379

Reference yield:

: 5673-98-3,63501-27-9,88080-30-2,63501-26-8
(S)-(-)-2-methyl-4-penten-1-ol

: 479202-78-3
(4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2.1: nBu₂BOTf; iPr₂NEt / CH₂Cl₂ / 0.75 h / 0 °C

2.2: Et₂AlCl / CH₂Cl₂; hexane / 2.6 h / -78 °C

2.3: 1.37 g / aq. H₂O₂ / CH₂Cl₂; hexane; methanol / 0.5 h / 0 °C

3.1: 91 percent / iPr₂NEt / CH₂Cl₂ / 19 h / 0 - 20 °C

With oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.1: Swern oxidation;
DOI:10.1055/s-2002-34379

Reference yield:

: 61866-32-8
(S)-2-methyl-4-pentenal

: 479202-78-3
(4R,5S)-3-[(2S,3S,4S)-3-(methoxymethoxy)-2,4-dimethylhept-6-enoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBu₂BOTf; iPr₂NEt / CH₂Cl₂ / 0.75 h / 0 °C

1.2: Et₂AlCl / CH₂Cl₂; hexane / 2.6 h / -78 °C

1.3: 1.37 g / aq. H₂O₂ / CH₂Cl₂; hexane; methanol / 0.5 h / 0 °C

2.1: 91 percent / iPr₂NEt / CH₂Cl₂ / 19 h / 0 - 20 °C

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1055/s-2002-34379