Technology Process of pentanoic acid, N-[(1,1-dimethylethoxy)carbonyl]-N-methylglycyl-(2E,5S,6R,7E)-8-[4-(aminomethyl)phenyl]-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl-, (5->2)-lactone, (2S)-
There total 8 articles about pentanoic acid, N-[(1,1-dimethylethoxy)carbonyl]-N-methylglycyl-(2E,5S,6R,7E)-8-[4-(aminomethyl)phenyl]-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl-, (5->2)-lactone, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(tert-butoxycarbonyl)sarcosine;
With
1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.75h;
pentanoic acid, N-[(2E,5S,6R,7E)-8-[4-(aminomethyl)phenyl]-5-hydroxy-6-methyl-1-oxo-2,7-octadienyl]-3-chloro-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl-, (3->1)-lactone, (2S)-;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
DOI:10.1021/jm0203884
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: m-chloroperbenzoic acid / CH2Cl2 / 20 °C
2.1: 72 percent / aq. perchloric acid / 1,2-dimethoxy-ethane / 6 h / 20 °C
3.1: 98 percent / aq. NaIO4 / tetrahydrofuran / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -50 - 20 °C
4.2: tetrahydrofuran / 3.75 h / -78 - 20 °C
4.3: 6.7 g / 1,1'-azobis(cyclohexanecarbonitrile); thiophenol / benzene / 5 h / Heating
5.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / -78 - 20 °C
6.1: 90 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
7.1: 57 percent / n-butylamine / ethanol / 48 h / 75 °C
8.1: 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 0.75 h / 20 °C
8.2: 71 percent / dimethylformamide / 3 h / 20 °C
With
sodium periodate; n-butyllithium; perchloric acid; tetrabutyl ammonium fluoride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
4.2: Wittig reaction;
DOI:10.1021/jm0203884
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 72 percent / aq. perchloric acid / 1,2-dimethoxy-ethane / 6 h / 20 °C
2.1: 98 percent / aq. NaIO4 / tetrahydrofuran / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -50 - 20 °C
3.2: tetrahydrofuran / 3.75 h / -78 - 20 °C
3.3: 6.7 g / 1,1'-azobis(cyclohexanecarbonitrile); thiophenol / benzene / 5 h / Heating
4.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / -78 - 20 °C
5.1: 90 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
6.1: 57 percent / n-butylamine / ethanol / 48 h / 75 °C
7.1: 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 0.75 h / 20 °C
7.2: 71 percent / dimethylformamide / 3 h / 20 °C
With
sodium periodate; n-butyllithium; perchloric acid; tetrabutyl ammonium fluoride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-butylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
3.2: Wittig reaction;
DOI:10.1021/jm0203884
